Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes

doi:10.1073/pnas.1525164113

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DOI Доступ к ресурсу на сайте издателя			10.1073/pnas.1525164113

#малярийные комары

#Y-хромосома

Title: Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes
Creator: Hall, Andrew Brantley
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Sharma, Atashi
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Cheng, Changde
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Akbari, Omar S
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Assour, Lauren
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Bergman, Nicholas H.
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Cagnetti, Alessia
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Crisanti, Andrea
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Dottorini, Tania
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Papathanos, Philippos-Aris
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Fiorentini, Elisa
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Galizi, Roberto
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Hnath, Jonathan
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Jiang, Xiaofang
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Sharakhov, Igor V.
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Sharakhova, Maria V.
Date: 2016
DOI: 10.1073/pnas.1525164113
Description: Y chromosomes control essential male functions in many species, including sex determination and fertility. However, because of obstacles posed by repeat-rich heterochromatin, knowledge of Y chromosome sequences is limited to a handful of model organisms, constraining our understanding of Y biology across the tree of life. Here, we leverage long single-molecule sequencing to determine the content and structure of the nonrecombining Y chromosome of the primary African malaria mosquito, Anopheles gambiae. We find that the An. gambiae Y consists almost entirely of a few massively amplified, tandemly arrayed repeats, some of which can recombine with similar repeats on the X chromosome. Sex-specific genome resequencing in a recent species radiation, the An. gambiae complex, revealed rapid sequence turnover within An. gambiae and among species. Exploiting 52 sex-specific An. gambiae RNA-Seq datasets representing all developmental stages, we identified a small repertoire of Y-linked genes that lack X gametologs and are not Y-linked in any other species except An. gambiae, with the notable exception of YG2, a candidate male-determining gene. YG2 is the only gene conserved and exclusive to the Y in all species examined, yet sequence similarity to YG2 is not detectable in the genome of a more distant mosquito relative, suggesting rapid evolution of Y chromosome genes in this highly dynamic genus of malaria vectors. The extensive characterization of the An. gambiae Y provides a long-awaited foundation for studying male mosquito biology, and will inform novel mosquito control strategies based on the manipulation of Y chromosomes.

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collection(s): Институт биологии, экологии, почвоведения, сельского и лесного хозяйства (Биологический институт) | Научное управление
Identifier: смотреть в электронном каталоге НБ ТГУ
Type: статьи в журналах
Source: Proceedings of the National Academy of Sciences of the United States of America. 2016. Vol. 113, № 15. P. E2114-E2123
Language: eng

Created: 30-03-2017

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Институт биологии, экологии, почвоведения, сельского и лесного хозяйства (Биологический институт)

Научное управление Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes